June 16, 2022



United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549


Re: Rubius Therapeutics, Inc.

Acceleration Request for Registration Statement on Form S-3

File No. 333- 265482


Ladies and Gentlemen:


Pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), Rubius Therapeutics, Inc. (the “Company”) hereby requests that the effective date of the above-referenced registration statement (the “Registration Statement”) be accelerated to June 21, 2022, at 4:30 p.m., Eastern Time, or as soon thereafter as practicable, unless we or our outside counsel, Goodwin Procter LLP, request by telephone that such Registration Statement be declared effective at some other time. In making this acceleration request, the Company acknowledges that it is aware of its responsibilities under the Act.


If you have any questions regarding this request, please contact Yasin Akbari of Goodwin Procter LLP at (617) 570-1013.


  /s/ Jose Carmona
  Jose Carmona
  Chief Financial Officer


cc:Maiken Keson-Brooks, Chief Legal Officer and Corporate Secretary, Rubius Therapeutics, Inc.
 Jacqueline Mercier, Esq., Goodwin Procter LLP
 Yasin Akbari, Esq., Goodwin Procter LLP