Rubius Therapeutics developed our proprietary RED PLATFORM® to generate red blood cells and genetically engineer them into a new class of cellular medicines, called Red Cell Therapeutics™ (RCTs). Our RED PLATFORM harnesses both the unique properties of red blood cells and the creative potential of genetic engineering to deliver on the promise of cellular therapy and transform how diseases are treated.
Red Cell Therapeutics are engineered to express biotherapeutic proteins within or on their cell surface to create highly selective, potent and allogeneic cellular medicines aimed at treating a range of diseases. They can potentially be used to kill tumors in cancer and regulate the immune system for the treatment of autoimmune diseases.
We are currently enrolling patients in a Phase 1/2 clinical trial of RTX-240; the trial has three separate Phase 1 arms: an ongoing monotherapy dose escalation arm in adults with relapsed/refractory or locally advanced solid tumors, an ongoing monotherapy dose escalation arm in adults with relapsed/refractory acute myeloid leukemia, and a combination therapy dose escalation arm with pembrolizumab in adults with relapsed/refractory or locally advanced solid tumors. We are also enrolling patients in a Phase 1 clinical trial of RTX-321 for the treatment of human papillomavirus 16-positive cancers. Additionally, the FDA cleared the IND for RTX-224 for the treatment of solid tumors, and we expect to begin dosing patients during the first quarter of 2022.